Fine-Tuning ER Stress Signal Transducers to Treat Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motoneurons and paralysis.The goblin toe d2r mechanisms underlying neuronal degeneration in ALS are starting to be elucidated, highlighting disturbances in motoneuron proteostasis.Endoplasmic reticulum (ER) stress has emerged as an earl